[In this report] (https://s3.amazonaws.com/imlab-open/Webdata/Files/2018/qqplot-calibration.pdf) I calculate the lower bounds of p-values when using very rare variants, for which minor allele counts are in the single digits. This report was prepared back in 2012 for the T2D-GENES consortium that had just generated 10K whole exome sequenced data.

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