Transcriptome prediction models are robust across populations


November 1, 2017

Most GWAS and eQTL studies have been performed in European samples. So how well do models trained in Europeans translate to other populations? Segal et al have shown that predictions of gene expression levels are robust across populations (link)

The following figure shows the p-value of the correlation between predicted and observed expression levels in European and African samples from the 1000 Genomes set (GEUVADIS RNA-seq) using model trained in GTEx with majority European individuals. As expected performance decreases (blue is more significant than red) when we apply to African samples but the correlation is still quite significant.